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2%色甘酸钠(Opticrom)与安慰剂治疗季节性变应性结膜炎的组间对比试验

Group comparative trial of 2% sodium cromoglycate (Opticrom) with placebo in the treatment of seasonal allergic conjunctivitis.

作者信息

Lindsay-Miller A C

出版信息

Clin Allergy. 1979 May;9(3):271-5. doi: 10.1111/j.1365-2222.1979.tb01553.x.

DOI:10.1111/j.1365-2222.1979.tb01553.x
PMID:111876
Abstract

A double-blind group comparative trial comparing Opticrom with a matching placebo, over a four-week period, in seasonal allergic conjunctivitis is reported. Overall assessment of treatment benefit made at the end of the trial by the patients and the clinician showed a statistically significant difference in favour of Opticrom. Of the patients on Opticrom, eighteen (90%) said they improved while in the clinicians opinion, seventeen (85%) improved. Six patients using Opticrom and five using placebo complained of stinging of the eyes, while one patient using placebo complained of his eyes becoming bloodshot and watering.

摘要

据报道,一项双盲组对比试验在季节性过敏性结膜炎患者中进行,为期四周,比较了色甘酸钠与匹配的安慰剂。试验结束时患者和临床医生对治疗效果的总体评估显示,色甘酸钠组具有统计学上的显著优势。使用色甘酸钠的患者中,18人(90%)表示病情有所改善,而临床医生认为有17人(85%)病情改善。6名使用色甘酸钠的患者和5名使用安慰剂的患者抱怨眼睛有刺痛感,而1名使用安慰剂的患者抱怨眼睛充血和流泪。

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1
Group comparative trial of 2% sodium cromoglycate (Opticrom) with placebo in the treatment of seasonal allergic conjunctivitis.2%色甘酸钠(Opticrom)与安慰剂治疗季节性变应性结膜炎的组间对比试验
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引用本文的文献

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Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness.季节性变应性结膜炎的局部治疗:疗效和有效性的系统评价与荟萃分析
Br J Gen Pract. 2004 Jun;54(503):451-6.
2
Conjunctival allergen challenge: models in the investigation of ocular allergy.结膜变应原激发试验:眼部过敏研究中的模型
Curr Allergy Asthma Rep. 2003 Jul;3(4):363-8. doi: 10.1007/s11882-003-0100-z.
3
Therapeutic options in ocular allergic disease.眼部过敏性疾病的治疗选择。
Drugs. 1995 Aug;50(2):208-21. doi: 10.2165/00003495-199550020-00002.
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Ocular sodium cromoglycate. An overview of its therapeutic efficacy in allergic eye disease.眼部用色甘酸钠。其在变应性眼病中治疗效果的概述。
Drugs. 1986 Feb;31(2):131-48. doi: 10.2165/00003495-198631020-00003.
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Drug treatment of allergic conjunctivitis. A review of the evidence.过敏性结膜炎的药物治疗。证据综述。
Drugs. 1992 Feb;43(2):154-76. doi: 10.2165/00003495-199243020-00003.