在艾滋病流行地区针对结核病直接督导治疗的一种新方法。
A novel approach to directly observed therapy for tuberculosis in an HIV-endemic area.
作者信息
Desvarieux M, Hyppolite P R, Johnson W D, Pape J W
机构信息
Division of Epidemiology, School of Public Health, Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, USA.
出版信息
Am J Public Health. 2001 Jan;91(1):138-41. doi: 10.2105/ajph.91.1.138.
OBJECTIVES
This study evaluated a novel approach to the delivery of directly observed therapy (DOT) for tuberculosis in Haiti.
METHODS
A total of 194 patients (152 HIV seropositive, 42 HIV seronegative) received daily unsupervised triple-drug therapy for 4 to 8 weeks, followed by twice-weekly 2-drug therapy for the remainder of the 6-month period. DOT was deferred until initiation of the twice-weekly phase.
RESULTS
A total of 169 of 194 patients (87.1%) completed the 6-month course. The program of deferred DOT had an effectiveness of 85%. Overall cost was reduced by approximately 40%.
CONCLUSIONS
Flexible approaches to DOT, integrating behavioral knowledge, cost considerations, and practicality may improve completion rates and program effectiveness.
目的
本研究评估了海地一种用于结核病直接督导治疗（DOT）的新方法。
方法
共有194名患者（152名HIV血清阳性，42名HIV血清阴性）接受了为期4至8周的每日无监督三联药物治疗，随后在6个月疗程的剩余时间里接受每周两次的二联药物治疗。DOT推迟至每周两次阶段开始时进行。
结果
194名患者中有169名（87.1%）完成了6个月疗程。延迟DOT方案的有效性为85%。总体成本降低了约40%。
结论
结合行为知识、成本考量和实用性的灵活DOT方法可能会提高完成率和方案有效性。
Zotero 插件