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氩蓝绿全视网膜光凝术后猴眼黄斑中心凹的光化学损伤

Photochemical injury to the foveomacula of the monkey eye following argon blue-green panretinal photocoagulation.

作者信息

Parver L M

机构信息

Wilmer Eye Institute, Johns Hopkins University, Baltimore, USA.

出版信息

Trans Am Ophthalmol Soc. 2000;98:365-74.

PMID:11190033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1298235/
Abstract

PURPOSE

Visual loss following panretinal photocoagulation was found in the Diabetic Retinopathy and the Early Treatment Diabetic Retinopathy Studies. This study was designed to test the hypothesis that light scattered in the monkey eye during a procedure designed to mimic a clinical panretinal photocoagulation (PRP) can produce a photochemical injury to the foveomacula.

METHODS

Ten eyes of 5 adult cynomologous monkeys underwent a PRP using an argon blue-green laser. Three eyes in 2 monkeys underwent a sham PRP, and an additional eye had a PRP with blue filtered slit-lamp illumination. The animals had baseline fundus photographs and fluorescein angiograms that were repeated 24 hours after the experimental procedure. Forty-eight hours after the experimental procedure, the eyes were removed and processed for light and electron microscopy.

RESULTS

There were no observable changes in the macula on fundus photography or fluorescein angiography 24 hours following PRP. Light and electron microscopy demonstrated changes in the retinal pigment epithelium and the outer photoreceptors, which were confined to the foveola. The control eyes showed no apparent effect from the slit lamp illumination used during the PRP.

CONCLUSIONS

The presence of histologic evidence of retinal injury in the foveomacula of the monkey eye after a procedure designed to mimic clinical PRP supports the hypothesis that photochemical retinal damage in the foveola may be associated with this procedure.

摘要

目的

在糖尿病视网膜病变和糖尿病视网膜病变早期治疗研究中发现了全视网膜光凝术后的视力丧失。本研究旨在检验这样一个假设，即在模拟临床全视网膜光凝（PRP）的过程中，猴眼内散射的光可对黄斑中心凹产生光化学损伤。

方法

5只成年食蟹猴的10只眼睛接受了氩蓝绿激光全视网膜光凝。2只猴子的3只眼睛接受了假全视网膜光凝，另外1只眼睛接受了带蓝色滤光片的裂隙灯照明下的全视网膜光凝。动物在实验前有基线眼底照片和荧光素血管造影，实验后24小时重复检查。实验后48小时，取出眼睛进行光镜和电镜检查。

结果

全视网膜光凝术后24小时，眼底照相或荧光素血管造影未观察到黄斑有明显变化。光镜和电镜检查显示视网膜色素上皮和外层光感受器有变化，且局限于中心小凹。对照眼在全视网膜光凝过程中使用的裂隙灯照明未显示明显影响。

结论

在模拟临床全视网膜光凝的操作后，猴眼黄斑中心凹出现视网膜损伤的组织学证据，支持了中心小凹光化学性视网膜损伤可能与该操作有关的假设。

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