Shimura Masahiko, Yasuda Kanako, Nakazawa Toru, Kano Tetsuya, Ohta Satsuki, Tamai Makoto
Department of Ophthalmology, Tohoku Graduate School of Medicine, Sendai, Japan.
Ophthalmology. 2003 Dec;110(12):2386-94. doi: 10.1016/j.ophtha.2003.05.008.
To investigate the alterations of macular thickness during and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy and good vision, and to compare the outcomes of weekly and biweekly treatments.
Prospective, comparative interventional case series.
Thirty-six patients with severe nonproliferative diabetic retinopathy or non-high-risk proliferative diabetic retinopathy whose visual acuity was 20/20 or better before PRP.
Seventy-two eyes of 36 patients underwent scatter PRP in 4 sessions. The macular thickness was measured by optical coherence tomography. The photocoagulation sessions were performed weekly to one eye and biweekly to the other eye. Each eye was selected at random.
Best-corrected visual acuity and macular thickness.
Visual acuities were maintained in 89% of eyes with weekly treatments and 92% of eyes with biweekly treatments. Macular thickness was increased transiently in the central macula in both eyes, more in the weekly treated eyes, and then decreased to control levels in eyes treated biweekly but remained thickened in eyes treated weekly.
For eyes with severe diabetic retinopathy and good vision, PRP with either weekly or biweekly treatment did not affect postoperative visual acuity. However, biweekly treatments allowed faster recovery of macular thickening after PRP than weekly treatments.
研究重度糖尿病视网膜病变且视力良好的患者在全视网膜光凝（PRP）期间及之后黄斑厚度的变化，并比较每周治疗和每两周治疗的效果。
前瞻性、比较性干预病例系列研究。
36例重度非增殖性糖尿病视网膜病变或非高危增殖性糖尿病视网膜病变患者，其在PRP治疗前视力为20/20或更好。
36例患者的72只眼分4次进行了散在PRP治疗。通过光学相干断层扫描测量黄斑厚度。一只眼每周进行一次光凝治疗，另一只眼每两周进行一次光凝治疗。每只眼随机选择治疗方式。
最佳矫正视力和黄斑厚度。
每周治疗的眼中89%以及每两周治疗的眼中92%的视力得以维持。双眼黄斑中心厚度均出现短暂增加，每周治疗的眼增加得更多，之后每两周治疗的眼黄斑厚度降至对照水平，而每周治疗的眼黄斑厚度仍保持增厚。
对于重度糖尿病视网膜病变且视力良好的眼，每周或每两周进行一次PRP治疗均不影响术后视力。然而，与每周治疗相比，每两周治疗使PRP后黄斑增厚恢复得更快。
