[斯法克斯地区献血者中抗巨细胞病毒抗体的流行率（输血中的价值）]

[Prevalence of anti-CMV antibodies in blood donors in the Sfax region (value in blood transfusion)].

作者信息

Gargouri J, Elleuch H, Karray H, Rekik H, Hammami A

机构信息

Centre Régional de Transfusion Sanguine de Sfax.

出版信息

Tunis Med. 2000 Aug-Sep;78(8-9):512-7.

PMID:11190729

Abstract

Detection of anti-CMV antibodies was carried out in sera of healthy blood donors, divided into groups of 20 according to age and sex. Sera were tested for anti-CMV by an ELISA test (Enzygnost anti-CMV/IgG-Behring). Among 280 sera, 272 were positive for IgG to CMV (97.14%). The prevalence of those antibodies was high in all age stratum (95-100%) but was higher in women than in men (98.57% versus 95.71%). The titre of IgG to CMV was superior to 12 Ul/ml in 56.43% of CMV positive donors. So, the leucocyte removal is the only alternative for the prevention of post-transfusional CMV infection. The high percentage of donors with anti-CMV antibodies level more than to 12 Ul/ml allow to consider the use of plasmapheresis for preparing specific immunoglobulins to CMV.

摘要

在健康献血者的血清中检测抗巨细胞病毒（CMV）抗体，根据年龄和性别将其分为每组20人的小组。通过酶联免疫吸附测定（ELISA）试验（Enzygnost抗CMV/IgG - 贝林）检测血清中的抗CMV。在280份血清中，272份CMV IgG呈阳性（97.14%）。这些抗体在所有年龄层中的流行率都很高（95 - 100%），但女性高于男性（98.57%对95.71%）。在56.43%的CMV阳性献血者中，CMV IgG滴度高于12 Ul/ml。因此，去除白细胞是预防输血后CMV感染的唯一选择。抗CMV抗体水平高于12 Ul/ml的献血者比例很高，这使得可以考虑使用血浆置换来制备抗CMV特异性免疫球蛋白。