Penchas S, Charuzi I, Boss J H
Eur J Clin Invest. 1979 Apr;9(2 Pt 1):161-6. doi: 10.1111/j.1365-2362.1979.tb01684.x.
Glomerulonephritis was induced in rats by multiple injections of rabbit anti-rat kidney serum. Colchicine was administered daily for 4 months to nephrotoxic serum treated rats and untreated control animals. Nephritic rats receiving colchicine had significantly less proteinuria and less glomerular damage than unprotected nephritis animals. A possible role for colchicine in the early treatment of human glomerulonephritis is suggested.
通过多次注射兔抗大鼠肾血清在大鼠中诱发肾小球肾炎。对接受肾毒性血清治疗的大鼠和未治疗的对照动物每天给予秋水仙碱，持续4个月。接受秋水仙碱治疗的肾炎大鼠蛋白尿和肾小球损伤明显少于未受保护的肾炎动物。提示秋水仙碱在人类肾小球肾炎早期治疗中可能发挥作用。
