Sachar E J, Altman N, Gruen P H, Glassman A, Halpern F S, Sassin J
Arch Gen Psychiatry. 1975 Apr;32(4):502-3. doi: 10.1001/archpsyc.1975.01760220114011.
After ingestion of 500 mg of levodopa, postmenopausal women had significantly diminished human growth hormone (HGH) responses (mean, 4.6 ng/ml), as compared with those of age-matched men (mean, 9.1 ng/ml; P smaller than .05). The differences between the groups were not related to plasma dopa concentrations. The HGH responses to levodopa of age-matched unipolar and bipolar depressed men, and of unipolar depressed postmenopausal women, did not differ significantly from their respective normal control groups. Depressive illness of these types does not appear to affect the HGH response to levodopa, once the effect of the menopause is taken into account.
摄入500毫克左旋多巴后，绝经后女性的人生长激素（HGH）反应显著降低（平均为4.6纳克/毫升），相比之下，年龄匹配的男性（平均为9.1纳克/毫升；P小于0.05）。两组之间的差异与血浆多巴浓度无关。年龄匹配的单相和双相抑郁男性以及单相抑郁绝经后女性对左旋多巴的HGH反应与各自的正常对照组相比无显著差异。一旦考虑到绝经的影响，这些类型的抑郁症似乎不会影响对左旋多巴的HGH反应。
