Chihara K, Kato Y, Maeda K, Ohgo S, Imura H
Acta Endocrinol (Copenh). 1976 Jan;81(1):19-27. doi: 10.1530/acta.0.0810019.
Immunoreactive plasma human prolactin (HPr) and human growth hormone (HGH) concentrations were measured in six normal young men with polygraphic sleep monitoring during normal sleep and during sleep in which l-dihydroxyphenylalanine (l-DOPA) was infused intravenously at a rate of 0.8 to 1.0 mg/min. The intravenous infusion of l-DOPA significantly suppressed the episodic release of HPr during sleep and the occurrence of rapid eye movement (REM) sleep. However, HGH release during sleep was not remarkably influenced by l-DOPA. These results suggest that central catecholaminergic neural mechanisms are related to both sleep-related HPr release and REM sleep, but do not play an important role in sleep-related HGH release.
在六名正常年轻男性中，于正常睡眠期间以及以0.8至1.0毫克/分钟的速率静脉输注左旋多巴（l-DOPA）的睡眠期间，通过多导睡眠监测测量免疫反应性血浆人催乳素（HPr）和人生长激素（HGH）浓度。静脉输注l-DOPA显著抑制了睡眠期间HPr的阵发性释放以及快速眼动（REM）睡眠的出现。然而，睡眠期间HGH的释放并未受到l-DOPA的显著影响。这些结果表明，中枢儿茶酚胺能神经机制与睡眠相关的HPr释放和REM睡眠均有关，但在睡眠相关的HGH释放中不发挥重要作用。
