Borisova L A, Babich L G, Shlykov S G, Kosterin S A
A. V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Ukr Biokhim Zh (1999). 2000 May-Jun;72(3):44-55.
The effects of subacute, acute and chronic ethanol exposure on the activity of Ca(2+)-accumulating systems of mitochondria and endoplasmic reticulum in myometrial cells of nonpregnant estrogen-treated rats were studied. It has been shown that the activity of Ca(2+)-accumulating system of mitochondria was higher than the activity of Ca(2+)-accumulating system of endoplasmic reticulum in myometrial cells from control, acute and subacute treated with ethanol rats. Under ethanol chronical assumption both Ca(2+)-accumulation in mitochondria and Ca(2+)-transporting activity of endoplasmic reticulum are inhibited. In the latter ease Mg2+, ATP-dependent Ca(2+)-pump lost its sensitivity to oxytocin.
研究了亚急性、急性和慢性乙醇暴露对未孕雌激素处理大鼠子宫肌层细胞线粒体和内质网钙蓄积系统活性的影响。结果表明，在对照组、急性和亚急性乙醇处理大鼠的子宫肌层细胞中，线粒体钙蓄积系统的活性高于内质网钙蓄积系统的活性。长期摄入乙醇会抑制线粒体中的钙蓄积和内质网的钙转运活性。在后一种情况下，镁离子、ATP依赖的钙泵对催产素失去敏感性。
