Borksova L A, Babich L G, Shlykov S G, Kosterin S A
A. V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Ukr Biokhim Zh (1999). 2000 Mar-Apr;72(2):28-35.
The effects of ethanol and other aliphatic alcohols on energy-dependent Ca2+ transport in endoplasmic reticulum and mitochondria were studied in digitonin-treated myometrium cells. The Ca2+ uptake in mitochondria increased (on 15-20%) with increasing methanol, ethanol and propanol concentrations in medium, whereas further rise of concentration inhibited this process. Treatments of myometrial cells with short-chain alcohols caused an inhibition of calcium uptake in endoplasmic reticulum. Butanol inhibited both calcium uptake in mitochondria and endoplasmic reticulum. Ca2+ accumulation in intracellular pools is inhibited by aliphatic alcohols in the following order of potency: butanol > propanol > ethanol > methanol. It is concluded that modifying effect of aliphatic alcohols on energy dependent calcium accumulation in intracellular membrane structures is defined as on origin of Ca(2+)-transporting system and (or) properties of these membrane structures so on properties of alcohols.
在洋地黄皂苷处理的子宫肌层细胞中，研究了乙醇和其他脂肪醇对内质网和线粒体中能量依赖性Ca2+转运的影响。随着培养基中甲醇、乙醇和丙醇浓度的增加，线粒体中的Ca2+摄取量增加（15%-20%），而浓度进一步升高则抑制了这一过程。用短链醇处理子宫肌层细胞会抑制内质网中的钙摄取。丁醇抑制线粒体和内质网中的钙摄取。脂肪醇按以下效力顺序抑制细胞内池中的Ca2+积累：丁醇>丙醇>乙醇>甲醇。得出的结论是，脂肪醇对细胞内膜结构中能量依赖性钙积累的调节作用取决于Ca(2+)转运系统的起源和（或）这些膜结构的特性，因此也取决于醇的特性。
