Berg G A, Siseles N, González A I, Ortiz O C, Tempone A, Wikinski R W
Department of Clinical Biochemistry of the School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Menopause. 2001 Jan-Feb;8(1):51-7. doi: 10.1097/00042192-200101000-00009.
To investigate the enzymatic activity of hepatic lipase (HL) in postmenopausal women (PMW) and reproductive age women (RAW); and to evaluate the relationship between this enzyme and the atherogenic intermediate density lipoproteins (IDL) and low density lipoproteins (LDL), and antiatherogenic high density lipoproteins (HDL) and its subfractions (HDL2 and HDL3).
We studied 55 PMW receiving no hormonal treatment in a cross-sectional study in comparison with a control group of 55 RAW, matched by body mass index. Follicle-stimulating hormone was > 40 mUI/ml in PMW and 3-12 mUI/ml in RAW. PMW presented at least 1 year of natural menopause and no more than 10 years of amenorrhea with E2 serum concentration < 15 pg/ml.
HL activity was significantly higher in PMW versus RAW (14.0 +/- 1.4 vs. 10.9 +/- 0.4 micromol of fatty acids/ml of postheparin plasma, respectively, mean +/- SEM, p < 0.001). In PMW, IDL cholesterol showed a positive correlation with LDL cholesterol (r = 0.28, p < 0.05), and HDL2 cholesterol was inversely correlated with HL activity (r = 0.31, p < 0.05). HL was positively correlated with plasma concentration of LDL cholesterol in both groups (r = 0.27, p < 0.05). The higher values of HL activity and IDL cholesterol were independent of age.
Higher HL activity is associated with a more atherogenic profile in PMW.
研究绝经后女性（PMW）和育龄期女性（RAW）肝脏脂肪酶（HL）的酶活性；并评估该酶与致动脉粥样硬化的中间密度脂蛋白（IDL）和低密度脂蛋白（LDL），以及抗动脉粥样硬化的高密度脂蛋白（HDL）及其亚组分（HDL2和HDL3）之间的关系。
我们进行了一项横断面研究，研究了55名未接受激素治疗的PMW，并与55名按体重指数匹配的RAW对照组进行比较。PMW的促卵泡激素>40 mUI/ml，RAW的促卵泡激素为3-12 mUI/ml。PMW自然绝经至少1年，闭经不超过10年，血清E2浓度<15 pg/ml。
与RAW相比，PMW的HL活性显著更高（分别为14.0±1.4与10.9±0.4微摩尔脂肪酸/毫升肝素后血浆，均值±标准误，p<0.001）。在PMW中，IDL胆固醇与LDL胆固醇呈正相关（r = 0.28，p<0.05），HDL2胆固醇与HL活性呈负相关（r = 0.31，p<0.05）。两组中HL均与LDL胆固醇的血浆浓度呈正相关（r = 0.27，p<0.05）。HL活性和IDL胆固醇的较高值与年龄无关。
较高的HL活性与PMW中更易致动脉粥样硬化的血脂谱相关。
