Rico-Sanz J, Moosavi M, Thomas E L, McCarthy J, Coutts G A, Saeed N, Bell J D
The Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England, UK.
Lipids. 2000 Dec;35(12):1313-8. doi: 10.1007/s11745-000-0647-2.
Magnetic resonance spectroscopy (1H MRS) and imaging (MRI) were used to investigate the effects of a bout of moderate prolonged exercise on intra (IMCL)- and extramyocellular lipid (EMCL) utilization in the soleus, tibialis anterior, and gastrocnemius muscles of five trained human subjects. MRI and 1H MRS measurements were obtained before and after a 90 min run on a calibrated treadmill at a velocity corresponding to 64 +/- 1.5% of each subjects' maximal rate of oxygen consumption. There were significant decreases in IMCL following exercise in the tibialis (pre: 22.37 +/- 4.33 vs. post: 15.16 +/- 3.25 mmol/kg dry wt; P < 0.01) and soleus (pre: 36.93 +/- 1.45 vs. post: 29.85 +/- 2.44 mmol/kg dry wt; P < 0.01) muscles. There was also a decrease in the gastrocnemius muscle, although this did not reach the level of significance (pre: 33.78 +/- 5.35 vs. post: 28.48 +/- 5.44 mmol/kg dry weight; P < 0.10). No significant changes were observed in EMCL or subcutaneous fat. In conclusion, this study showed that IMCL were significantly utilized in the tibialis and soleus muscles of aerobically endurance-trained humans. The absence of significant utilization of IMCL in the gastrocnemius may reflect differences in fiber type and/or intensity of contraction for each muscle group.
采用磁共振波谱（1H MRS）和成像（MRI）技术，研究了一次适度长时间运动对5名受过训练的健康受试者比目鱼肌、胫骨前肌和腓肠肌细胞内（IMCL）和细胞外脂质（EMCL）利用情况的影响。在经过校准的跑步机上以相当于每个受试者最大耗氧率64±1.5%的速度进行90分钟跑步前后，分别进行MRI和1H MRS测量。运动后，胫骨前肌（运动前：22.37±4.33 vs.运动后：15.16±3.25 mmol/kg干重；P<0.01）和比目鱼肌（运动前：36.93±1.45 vs.运动后：29.85±2.44 mmol/kg干重；P<0.01）的IMCL显著降低。腓肠肌的IMCL也有所下降，尽管未达到显著水平（运动前：33.78±5.35 vs.运动后：28.48±5.44 mmol/kg干重；P<0.10）。EMCL和皮下脂肪未观察到显著变化。总之，本研究表明，在有氧耐力训练的人体中，胫骨前肌和比目鱼肌中的IMCL被大量利用。腓肠肌中IMCL未被大量利用，可能反映了每个肌肉群的纤维类型和/或收缩强度的差异。
