Jee S H, He J, Appel L J, Whelton P K, Suh I, Klag M J
Department of Epidemiology and Disease Control, Yonsei University Graduate School of Health Science and Management, Seoul, Republic of Korea.
Am J Epidemiol. 2001 Feb 15;153(4):353-62. doi: 10.1093/aje/153.4.353.
Coffee drinking has been associated with increased serum cholesterol levels in some, but not all, studies. A Medline search of the English-language literature published prior to December 1998, a bibliography review, and consultations with experts were performed to identify 14 published trials of coffee consumption. Information was abstracted independently by two reviewers using a standardized protocol. With a random-effects model, treatment effects were estimated by pooling results from individual trials after weighting the results by the inverse of total variance. A dose-response relation between coffee consumption and both total cholesterol and LDL cholesterol was identified (p < 0.01). Increases in serum lipids were greater in studies of patients with hyperlipidemia and in trials of caffeinated or boiled coffee. Trials using filtered coffee demonstrated very little increase in serum cholesterol. Consumption of unfiltered, but not filtered, coffee increases serum levels of total and LDL cholesterol.
在一些但并非所有研究中，喝咖啡都与血清胆固醇水平升高有关。我们检索了1998年12月之前发表的英文文献数据库Medline，进行了文献综述，并咨询了专家，以确定14项已发表的咖啡消费试验。两名评审员使用标准化方案独立提取信息。采用随机效应模型，在对结果进行总方差倒数加权后，通过汇总各个试验的结果来估计治疗效果。确定了咖啡消费与总胆固醇和低密度脂蛋白胆固醇之间的剂量反应关系（p<0.01）。在高脂血症患者的研究以及含咖啡因或煮咖啡的试验中，血脂升高更为明显。使用过滤咖啡的试验显示血清胆固醇几乎没有增加。饮用未过滤咖啡（而非过滤咖啡）会使总胆固醇和低密度脂蛋白胆固醇的血清水平升高。
