Süssmuth S D, Reiber H, Tumani H
Department of Neurology, University of Ulm, Germany.
Neurosci Lett. 2001 Mar 9;300(2):95-8. doi: 10.1016/s0304-3940(01)01556-7.
Tau protein (tau) is primarily localised in neurons, and after brain parenchymal damage its release into cerebrospinal fluid (CSF) is increased. The particular influences of blood-CSF barrier function and of disease topography on CSF tau levels have not been studied yet. CSF tau concentrations determined by enzyme-immunoassay in various neurological diseases (n = 61) were not dependent upon blood-CSF barrier dysfunction. Significant elevation of tau levels in patients with meningoencephalitis and cerebral hemorrhage indicates brain parenchymal damage. In contrast, tau levels remained normal in patients with bacterial meningitis if encephalitic complications did not occur. In patients with Guillain-Barré syndrome tau levels were low. Increased tau levels in active multiple sclerosis compared to clinically nonactive states indicate axonal pathology in active disease.
tau蛋白主要定位于神经元中，脑实质损伤后其释放到脑脊液（CSF）中的量会增加。血脑屏障功能和疾病部位对脑脊液tau水平的具体影响尚未得到研究。通过酶免疫测定法测定的各种神经系统疾病（n = 61）患者脑脊液中的tau浓度并不依赖于血脑屏障功能障碍。脑膜脑炎和脑出血患者tau水平的显著升高表明脑实质损伤。相比之下，如果没有发生脑炎并发症，细菌性脑膜炎患者的tau水平保持正常。格林-巴利综合征患者的tau水平较低。与临床非活动状态相比，活动性多发性硬化症患者tau水平升高表明活动期疾病存在轴索病变。
