Heckmann S M, Heckmann J G, HiIz M J, Popp M, Marthol H, Neundörfer B, Hummel T
Department of Prosthodontics, University of Erlangen-Nuremberg, Glückstrasse 11, 91054 Erlangen, Germany Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany.
Pain. 2001 Feb 15;90(3):281-286. doi: 10.1016/S0304-3959(00)00410-3.
The pathophysiology of burning mouth syndrome (BMS) is largely unknown. Thus, the aim was to study oral mucosal blood flow in BMS-patients using laser Doppler flowmetry (LDF). Thirteen BMS patients (11 female, two male; mean age+/-SD 64.3+/-7.9 years, mean disease duration 18.9+/-6.2 months) and 13 healthy non-smoking controls matched for age and gender (11 female, two male; mean age 64.7+/-8.1 years) were investigated. Using the LDF technique mucosal blood flow (mBF) was measured at the hard palate, the tip of the tongue, on the midline of the oral vestibule, and on the lip. Measurements were made at rest and over 2 min following dry ice application of 10 s duration using a pencil shaped apparatus. In addition, blood pressure (BP), heart rate (HR), peripheral cutaneous blood flow, and transcutaneous pCO(2) were continuously recorded. Mucosal blood flow (mBF) increased at all measurement sites in response to dry ice application (P<0.001) with peak flow at 0.5--1.5 min after stimulation onset. During the following 1.5--2 min, blood flow decreased at all sites with a tendency to return to baseline towards the end of the observation period. Except for BP and peripheral blood flow, all of the cardiovascular changes exhibited significant changes during the observation period; no differences between groups were detected. When compared to healthy controls BMS patients generally exhibited larger changes in mBF. These changes were significant for recordings made on the hard palate (F[1,24]=13.9, P<0.001). Dry ice stimulation appears to be an effective, non-invasive and reasonably tolerable means to investigate mucosal blood flow at different mucosal sites. In general, vasoreactivity in BMS patients was higher than in healthy controls. BMS patients exhibited a higher response on the hard palate compared to controls. These changes in oral blood flow appear to be specifically related to BMS symptoms indicating a disturbed vasoreactivity.
灼口综合征（BMS）的病理生理学在很大程度上尚不清楚。因此，本研究旨在使用激光多普勒血流仪（LDF）研究BMS患者的口腔黏膜血流量。研究对象为13例BMS患者（11例女性，2例男性；平均年龄±标准差为64.3±7.9岁，平均病程18.9±6.2个月）和13名年龄和性别相匹配的健康非吸烟对照者（11例女性，2例男性；平均年龄64.7±8.1岁）。使用LDF技术在硬腭、舌尖、口腔前庭中线和唇部测量黏膜血流量（mBF）。使用铅笔状仪器在静息状态下以及在持续10秒的干冰应用后2分钟内进行测量。此外，连续记录血压（BP）、心率（HR）、外周皮肤血流量和经皮二氧化碳分压。干冰应用后，所有测量部位的黏膜血流量（mBF）均增加（P<0.001），刺激开始后0.5-1.5分钟达到血流峰值。在随后的1.5-2分钟内，所有部位的血流均下降，在观察期结束时趋于恢复至基线水平。除血压和外周血流外，所有心血管变化在观察期内均表现出显著变化；未检测到组间差异。与健康对照者相比，BMS患者的mBF变化通常更大。这些变化在硬腭记录中具有显著性（F[1,24]=13.9，P<0.001）。干冰刺激似乎是一种有效、非侵入性且耐受性良好的方法，可用于研究不同黏膜部位的黏膜血流量。总体而言，BMS患者的血管反应性高于健康对照者。与对照者相比，BMS患者在硬腭上的反应更高。口腔血流的这些变化似乎与BMS症状特别相关，表明血管反应性紊乱。
