聚合马达

The polymerization motor.

作者信息

Theriot J A

机构信息

Department of Biochemistry and Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.

出版信息

Traffic. 2000 Jan;1(1):19-28. doi: 10.1034/j.1600-0854.2000.010104.x.

DOI:10.1034/j.1600-0854.2000.010104.x

PMID:11208055

Abstract

Polymerization and depolymerization of actin filaments and microtubules are thought to generate force for movement in various kinds of cell motility, ranging from lamellipodial protrusion to chromosome segregation. This article reviews the thermodynamic and physical theories of how a nonequilibrium polymerization reaction can be used to transduce chemical energy into mechanical energy, and summarizes the evidence suggesting that actin polymerization produces motile force in several biological systems.

摘要

肌动蛋白丝和微管的聚合和解聚被认为在从片状伪足突出到染色体分离等各种细胞运动中产生运动力。本文综述了关于非平衡聚合反应如何将化学能转化为机械能的热力学和物理理论，并总结了表明肌动蛋白聚合在几个生物系统中产生运动力的证据。