Salvadori Alberto, Bonanno Claudia, Serpelloni Mattia, McMeeking Robert M
The Mechanobiology Research Center, UNIBS, 25123, Brescia, Italy.
Department of Mechanical and Industrial Engineering, Università degli Studi di Brescia, via Branze 38, 25123, Brescia, Italy.
Sci Rep. 2024 Aug 8;14(1):18384. doi: 10.1038/s41598-024-69422-3.
The fundamental question of how forces are generated in a motile cell, a lamellipodium, and a comet tail is the subject of this note. It is now well established that cellular motility results from the polymerization of actin, the most abundant protein in eukaryotic cells, into an interconnected set of filaments. We portray this process in a continuum mechanics framework, claiming that polymerization promotes a mechanical swelling in a narrow zone around the nucleation loci, which ultimately results in cellular or bacterial motility. To this aim, a new paradigm in continuum multi-physics has been designed, departing from the well-known theory of Larché-Cahn chemo-transport-mechanics. In this note, we set up the theory of network growth and compare the outcomes of numerical simulations with experimental evidence.
关于运动细胞、片状伪足和彗星尾中力是如何产生的基本问题是本笔记的主题。目前已经明确，细胞运动是由肌动蛋白（真核细胞中最丰富的蛋白质）聚合成相互连接的细丝网络所致。我们在连续介质力学框架中描述这一过程，认为聚合作用会在成核位点周围的狭窄区域促进机械膨胀，最终导致细胞或细菌运动。为此，我们设计了一种连续介质多物理场的新范式，它不同于著名的拉切 - 卡恩化学传输 - 力学理论。在本笔记中，我们建立了网络生长理论，并将数值模拟结果与实验证据进行比较。
