Sobaniec H, Sobaniec-Lotowska M E
Department of Dental Prosthetics of Medical University, ul. M. Curie-Skłodowskiej 24a, 15-276 Białystok, Poland.
Med Sci Monit. 2000 Sep-Oct;6(5):875-81.
The problem of teeth loss as a result of periodontitis is growing continuously. In the study we aimed to show the correlation between the disease and lipid metabolism disorders. We performed morphological examinations of hard tissues of rats' periodontium in the course of experimental ligature-induced periodontitis and we demonstrated the destruction of alveolodental ligament. The following changes were observed: degenerative changes including necrosis within periodontium, progressive destruction of bone mass of alveolar process of the mandible in the region of inflammatory infiltration. Simultaneously, biochemical examinations of blood serum were performed revealing decrease of basic antioxidant enzymes activities: SOD, GSH-Px, GSH-R with simultaneous increase of MDA--the final product of lipid peroxidation.
牙周炎导致牙齿缺失的问题正在持续增加。在本研究中，我们旨在揭示该疾病与脂质代谢紊乱之间的相关性。在实验性结扎诱导的牙周炎过程中，我们对大鼠牙周硬组织进行了形态学检查，并证实了牙槽骨韧带的破坏。观察到以下变化：牙周组织内出现包括坏死在内的退行性变化，下颌牙槽突骨量在炎症浸润区域逐渐破坏。同时，对血清进行生化检查发现，基本抗氧化酶活性下降：超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、谷胱甘肽还原酶（GSH-R），同时脂质过氧化终产物丙二醛（MDA）增加。
