Veljovic Tanja, Djuric Milanko, Mirnic Jelena, Gusic Ivana, Maletin Aleksandra, Ramic Bojana, Neskovic Isidora, Vukoje Karolina, Brkic Snezana
Department of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Dentistry Clinic of Vojvodina, 21000 Novi Sad, Serbia.
J Clin Med. 2022 Jun 23;11(13):3617. doi: 10.3390/jcm11133617.
Lipid peroxidation (LPO) participates in the development of various diseases, including periodontitis, and malondialdehyde (MDA) is its terminal product. Therefore, in the present study, salivary and plasma MDA levels in 30 periodontitis patients were compared to those in 20 healthy controls, as well as in relation to periodontal therapy in order to assess its effectiveness. Periodontal status was assessed via plaque index, gingival index, papilla bleeding index, probing depth and clinical attachment level, while salivary and plasma MDA levels were determined by the ELISA method. The periodontitis group had a significantly greater salivary (2.99 pmol/µL) and plasma (0.50 pmol/µL) MDA levels relative to the healthy controls (1.33 pmol/µL and 0.40 pmol/µL, respectively). Three months after the periodontal therapy completion, although salivary MDA levels were significantly lower than those measured at the baseline (p < 0.001), the reduction in plasma MDA was not statistically significant (p > 0.05). These findings indicate that, while inflammatory processes in periodontium may increase local and systemic lipid peroxidation, periodontal therapy can result in a significant decrease in salivary, but not plasma, MDA levels.
脂质过氧化（LPO）参与包括牙周炎在内的多种疾病的发展过程，丙二醛（MDA）是其终产物。因此，在本研究中，比较了30名牙周炎患者与20名健康对照者的唾液和血浆MDA水平，并研究了其与牙周治疗的关系，以评估治疗效果。通过菌斑指数、牙龈指数、龈乳头出血指数、探诊深度和临床附着水平评估牙周状况，采用酶联免疫吸附测定法（ELISA法）测定唾液和血浆MDA水平。与健康对照者（分别为1.33 pmol/µL和0.40 pmol/µL）相比，牙周炎组的唾液（2.99 pmol/µL）和血浆（0.50 pmol/µL）MDA水平显著更高。牙周治疗完成三个月后，尽管唾液MDA水平显著低于基线测量值（p < 0.001），但血浆MDA的降低无统计学意义（p > 0.05）。这些发现表明，虽然牙周组织的炎症过程可能会增加局部和全身的脂质过氧化，但牙周治疗可使唾液MDA水平显著降低，而血浆MDA水平则无明显变化。
