Buckle D R, Cantello B C, Smith H, Spicer B A
J Med Chem. 1975 Apr;18(4):391-4. doi: 10.1021/jm00238a014.
Twenty-four substituted 4-hydroxy-3-nitrocoumarins have been prepared for nitration of the corresponding 4-hydroxycoumarins. All were found to possess antiallergic activity as measured by the homocytotropic antibody-antigen induced passive cutaneous anaphylaxis reaction in the rat.
已制备了24种取代的4-羟基-3-硝基香豆素,用于相应4-羟基香豆素的硝化反应。通过大鼠体内亲同种细胞抗体-抗原诱导的被动皮肤过敏反应测定,发现所有这些化合物均具有抗过敏活性。