Antiallergic activity of omega-nitroacetophenones.
作者信息
Buckle D R, Cantello B C, Morgan N J, Smith H, Spicer B A
出版信息
J Med Chem. 1975 Jul;18(7):733-6. doi: 10.1021/jm00241a018.
PMID:1151994
Abstract
Selected omega-nitroacetophenones, formed by the alcoholic cleavage of 2-nitroindandiones, have been shown to inhibit the homocytotropic antibody-antigen induced passive cutaneous analhylaxis reaction in the rat. The enzymatic cyclization of these derivatives to the parent nitroindandione has been demonstrated both in vivo and in vitro and this process is suggested as a possible prerequisite to biological activity.
摘要
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