Bernstein G A, Hektner J M, Borchardt C M, McMillan M H
Division of Child and Adolescent Psychiatry, University of Minnesota, Minneapolis, USA.
J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):206-13. doi: 10.1097/00004583-200102000-00015.
To conduct a 1-year follow-up of anxious-depressed school-refusing adolescents who participated in an 8-week study of imipramine versus placebo, each in combination with cognitive-behavioral therapy.
Sixty-five percent (41 of 63) of the randomly assigned subjects returned for follow-up evaluation, which consisted of diagnostic interviews, clinician rating scales for anxiety and depression, family functioning measure, and a questionnaire regarding interim treatments and school programs.
From the adolescent and/or parent perspective, 64.1% met criteria for an anxiety disorder and 33.3% met criteria for a depressive disorder. Remission rates and acquisition rates for specific anxiety and depressive disorders were determined. In the follow-up period, 67.5% received at least one psychotropic medication trial and 77.5% had outpatient therapy. Higher level of somatic complaints on the Anxiety Rating for Children-Revised Physiological subscale at baseline predicted more severe depression on the Children's Depression Rating Scale-Revised at follow-up (p = .029).
In this naturalistic follow-up study, there was high utilization of mental health interventions. In addition, a substantial number of subjects met criteria for anxiety and/or depressive disorders 1 year after treatment. Investigation of duration of acute treatments and evaluation of maintenance treatments for school refusal is needed.
对参与为期8周的丙咪嗪与安慰剂对照研究(二者均联合认知行为疗法)的焦虑抑郁型拒学青少年进行为期1年的随访。
65%(63名中的41名)随机分组的受试者返回接受随访评估,评估包括诊断访谈、焦虑和抑郁的临床评定量表、家庭功能测量以及一份关于中期治疗和学校项目的问卷。
从青少年和/或家长的角度来看,64.1%符合焦虑症标准,33.3%符合抑郁症标准。确定了特定焦虑症和抑郁症的缓解率和患病率。在随访期间,67.5%至少接受过一次精神药物试验,77.5%接受过门诊治疗。基线时儿童焦虑评定量表修订版生理子量表上较高水平的躯体主诉预示着随访时儿童抑郁评定量表修订版上更严重的抑郁(p = 0.029)。
在这项自然主义的随访研究中,心理健康干预的利用率很高。此外,相当数量的受试者在治疗1年后符合焦虑症和/或抑郁症标准。需要对急性治疗的持续时间进行调查,并对拒学的维持治疗进行评估。