Lykova E A, Vorob'ev A A, Bokovoĭ A G, Murashova A O
Central Clinical Hospital of the Head Office of the President of the Russian Federation, Moscow, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2001 Mar-Apr(2):65-7.
The state of interferon status was studied in 46 hospitalized children: 33 patients with complicated forms of acute respiratory virus infection (ARVI), such as pneumonia, bronchitis, etc., and 13 patients with vegetovascular dystonia (used as a comparison group). The study revealed that in patients with acute infections of the upper and lower respiratory tract considerable changes in their interferon system were registered. Children with ARVI were treated with Bifidumbacterin forte, a probiotic preparation, in large doses. Bifidumbacterin forte was found to produce a regulatory effect on the interferon system by enhancing the induction of alpha- and gamma-interferon and decreasing the production of serum interferon. The experience of using Bifidumbacterin forte in large doses proved that the preparation was well tolerated and could be used for the correction of interferon status.
对46名住院儿童的干扰素状态进行了研究：33例患有急性呼吸道病毒感染（ARVI）的复杂形式，如肺炎、支气管炎等，13例患有植物神经血管性肌张力障碍（作为对照组）。研究发现，上、下呼吸道急性感染患者的干扰素系统有显著变化。ARVI患儿接受了大剂量的益生菌制剂强力双歧杆菌治疗。发现强力双歧杆菌通过增强α-和γ-干扰素的诱导并减少血清干扰素的产生，对干扰素系统产生调节作用。大剂量使用强力双歧杆菌的经验证明，该制剂耐受性良好，可用于纠正干扰素状态。
