抗抑郁药作为镇痛药：随机对照试验综述
Antidepressants as analgesics: a review of randomized controlled trials.
作者信息
Lynch M E
机构信息
Queen Elizabeth II Health Sciences Centre and Department of Psychiatry, Dalhousie University, Halifax, NS.
出版信息
J Psychiatry Neurosci. 2001 Jan;26(1):30-6.
Abstract
This review provides an overview of 59 randomized placebo-controlled trials that examined the analgesic effect of antidepressants. To summarize, there is significant evidence that the tricyclic group of antidepressants is analgesic and that trazodone is not; the data regarding selective serotonin reuptake inhibitors are conflicting. To date, there are no randomized controlled trials examining the potential analgesic action of nefazodone or venlafaxine, but on the basis of initial clinical reports and its structural similarity to other analgesics, venlafaxine shows promise as an analgesic.
摘要
本综述概述了59项检验抗抑郁药镇痛效果的随机安慰剂对照试验。总而言之，有充分证据表明三环类抗抑郁药具有镇痛作用，而曲唑酮则没有；关于选择性5-羟色胺再摄取抑制剂的数据存在矛盾。迄今为止，尚无检验奈法唑酮或文拉法辛潜在镇痛作用的随机对照试验，但根据初步临床报告及其与其他镇痛药的结构相似性，文拉法辛有望成为一种镇痛药。
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