微管动力学的结构观点。
A structural view of microtubule dynamics.
作者信息
Nogales E
机构信息
Department of Molecular and Cell Biology, UC Berkeley, California 94720-3200, USA.
出版信息
Cell Mol Life Sci. 1999 Oct 1;56(1-2):133-42. doi: 10.1007/s000180050012.
Abstract
The essential microtubule property of dynamic instability is based on the binding, hydrolysis and exchange of GTP in each tubulin dimer. The recent high-resolution structures of tubulin and the microtubule have given us the first view at atomic level of properties such as nucleotide exchangeability, the linkage between polymerization and nucleotide hydrolysis. and the origin of microtubule destabilization, as well as the mode of action of antimitotic agents such as taxol.
摘要
动态不稳定性这一微管的基本特性基于每个微管蛋白二聚体中鸟苷三磷酸（GTP）的结合、水解和交换。最近微管蛋白和微管的高分辨率结构使我们首次在原子水平上了解了诸如核苷酸交换性、聚合作用与核苷酸水解之间的联系、微管去稳定作用的起源，以及诸如紫杉醇等抗有丝分裂剂的作用方式等特性。
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