Melo S S, Meirelles M S, Jordão Júnior A A, Vannucchi H
Dept. of Internal Medicine, Nutrition Division, Faculty of Medicine of Ribeirão Preto, São Paulo University, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto/SP, Brazil.
Int J Vitam Nutr Res. 2000 Dec;70(6):321-3. doi: 10.1024/0300-9831.70.6.321.
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione. Urinary N-methylnicotinamide excretion was much more marked in the supplemented group, whereas the difference between deficient and control animals was nonsignificant.
在大鼠中，烟酰胺的补充或缺乏可能会干扰氧化平衡，过量会导致通过硫代巴比妥酸反应物（TBARS）测量的脂质过氧化增加，而缺乏则会导致维生素E和谷胱甘肽等抗氧化剂的消耗增加。补充组的尿N-甲基烟酰胺排泄更为明显，而缺乏组与对照组动物之间的差异不显著。
