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[二氧化碳激光与寻常疣]

[The CO2 laser and verruca vulgaris].

作者信息

Takac S

机构信息

Zavod za sudsku medicinu, Institut medicinskih sluzbi, Medicinski fakultet, Novi Sad.

出版信息

Med Pregl. 2000 Jul-Aug;53(7-8):389-93.

PMID:11214484
Abstract

INTRODUCTION

Verruca vulgaris, or a common wart, is a benign epithelial contagious tumour. It is usually flesh-coloured hyperkeratotic papule of a small size (few millimetres in diameter) although sometimes it may reach up to 2 cm in diameter. Milder, more conservative chemical therapy often requires weeks or months and is often unsuccessful. More aggressive therapy (e.g. electrodesiccation and curettage) may result in significant morbidity, tissue damage, and scarring. Plantar warts are particularly problematic. CO2 laser has numerous applications in dermatology and dermatologic surgery. It is versatile, being either a vaporising tool or a light scalpel. CO2 laser is an excellent modality for treating problematic or recurrent warts. In our experience it has now become the method of choice for warts. The aim of the present investigation was to evaluate the efficacy of the laser treatment in comparison to more conventional forms of treatment.

MATERIAL AND METHODS

Surgical laser was used at 15 W power at superpulsating, pulsating and continuous beam. The wavelength was 10,600 nm and the laser was used at infrared spectrum. Active substance was CO2 in combination with nitrogen and helium at following proportion: CO2:N2:He = 4.5%:13.5%:82%. It was used under the pressure of 20-80 mbars. Lesions are treated with laser in a focused mode at low to medium-power density in a series of brief pulses (0.05-0.1 sec). Treatment was carried out under magnified vision (2.5x magnifying loupes) in order to see all small satellite warts and to judge more precisely when all wart tissue has been vaporized. All interventions were performed under local anaesthesia with either carticaine-chloride or 2% lidocaine-chloride. All interventions were performed between 1992-1996 in an outpatient clinic. Warts were excised with a combination of vaporization and resection of the wart root.

RESULTS

The laser beam promptly sterilized the operative field more efficiently than any other commonly used disinfectant. Healing was by granulation and the post-operative period was relatively painless for the patient. Healing resulted in either no scar or a supple flexible scar which was asymptomatic.

DISCUSSION

Verruca vulgaris most often occurs on fingers and hands of children and teenagers (most commonly between ages 18 to 20). Resistance to therapy is common, and recurrences are frequent. Carbon dioxide laser is a high-precision, bloodless light scalpel used for incising and excising tissues with sealing of small blood vessels. It is the treatment of choice for local destruction of intraephithelial neoplastic lesions. The carbon dioxide beam may be used to remove tissue in one of two ways. First, the lesion may be vaporized until a bed of healthy tissue is reached. The second and better technique is to use the beam as a scalpel to excise a lesion with appropriate margins. Post-operative morbidity and complications are low, and long-term results appear to be excellent.

CONCLUSION

Laser therapy of common warts is a novel form of treatment of these papillomavirus-induced skin tumours. Our results show that this method has numerous advantages over more conventional forms of treatment.

摘要

引言

寻常疣是一种良性上皮性传染性肿瘤。它通常是小尺寸(直径几毫米)的肉色角化过度丘疹,不过有时直径可达2厘米。较温和、更保守的化学疗法通常需要数周或数月,且常常不成功。更积极的疗法(如电干燥法和刮除术)可能会导致明显的发病率、组织损伤和瘢痕形成。跖疣尤其棘手。二氧化碳激光在皮肤科和皮肤外科有众多应用。它用途广泛,既可以作为汽化工具,也可以作为光刀。二氧化碳激光是治疗棘手或复发性疣的极佳方式。根据我们的经验,它现已成为治疗疣的首选方法。本研究的目的是评估激光治疗与更传统治疗方式相比的疗效。

材料与方法

手术激光以15瓦功率用于超脉冲、脉冲和连续光束模式。波长为10,600纳米,激光用于红外光谱。活性物质是二氧化碳与氮气和氦气按以下比例混合:二氧化碳:氮气:氦气 = 4.5%:13.5%:82%。在20 - 80毫巴的压力下使用。病变以聚焦模式在低至中等功率密度下通过一系列短脉冲(0.05 - 0.1秒)用激光治疗。治疗在放大视野(2.5倍放大放大镜)下进行,以便看到所有小的卫星疣,并更精确地判断何时所有疣组织都已汽化。所有干预均在局部麻醉下进行,使用的麻醉剂为盐酸卡替卡因或2%盐酸利多卡因。所有干预均在1992年至1996年期间在门诊进行。疣通过汽化和切除疣根相结合的方式切除。

结果

激光束比任何其他常用消毒剂更迅速有效地对手术区域进行了消毒。愈合通过肉芽组织形成,术后患者相对无痛。愈合后要么没有瘢痕,要么形成柔软灵活且无症状的瘢痕。

讨论

寻常疣最常出现在儿童和青少年的手指和手部(最常见于18至20岁之间)。对治疗的抵抗很常见,复发也频繁。二氧化碳激光是一种高精度、无血的光刀,用于切割和切除组织并封闭小血管。它是上皮内肿瘤性病变局部破坏的首选治疗方法。二氧化碳光束可以通过两种方式之一用于去除组织。第一种方式是将病变汽化,直到到达健康组织床。第二种也是更好的技术是将光束用作手术刀,以适当的边缘切除病变。术后发病率和并发症较低,长期效果似乎很好。

结论

寻常疣的激光治疗是这些乳头瘤病毒引起的皮肤肿瘤的一种新型治疗方式。我们的结果表明,这种方法比更传统的治疗方式有许多优点。

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