Glew R H, Levin J
Proc Soc Exp Biol Med. 1975 Feb;148(2):508-10. doi: 10.3181/00379727-148-38572.
The possibility that endotoxin or an endotoxin-like substance plays a role in malaria has been suggested by the clinical similarity between human malaria and the febrile reaction to endotoxins, as well as the occurrence of endotoxin tolerance in humans infected with malaria. However, endotoxin or endotoxin-like activity was not demonstrable, using the Limulus test, in the plasma of humans or monkeys infected with plasmodia. The data indicate that the febrile paroxysm of malarial infection is not associated with detectable levels of endotoxin in the blood.
人类疟疾与内毒素发热反应之间的临床相似性，以及感染疟疾的人类体内出现内毒素耐受性，提示内毒素或类内毒素物质在疟疾中发挥作用。然而，使用鲎试剂检测法，在感染疟原虫的人类或猴子血浆中未证实存在内毒素或类内毒素活性。数据表明，疟疾感染的发热发作与血液中可检测到的内毒素水平无关。
