Carboncini M C, Manzoni D, Strambi S, Bonuccelli U, Pavese N, Andre P, Rossi B
Department of Neuroscience, University of Pisa, Italy.
Mov Disord. 2001 Jan;16(1):47-57. doi: 10.1002/1531-8257(200101)16:1<47::aid-mds1012>3.0.co;2-v.
The kinematics characteristics of an upper arm extension of large amplitude (90 degrees) performed in the horizontal plane and the simultaneous activity of the shoulder muscles were recorded in 12 parkinsonian patients and in six normal control subjects. The movement, triggered by an acoustic "go" signal, was preceded by an isometric adduction. Within the whole population of individuals (n = 18) a strong, positive correlation was observed between the root mean square value of agonist EMG activity, evaluated during the acceleration phase of the movement, and both peak velocity and acceleration. In six patients tremor bursts at the frequency of 8-14 Hz (action tremor) were observed during the movement phase in the anterior, middle, and posterior deltoid: all these patients showed low root mean square values and were bradykinetic with respect to the control subjects. The remaining six patients did not show this action tremor during the movement phase. All but one had an agonist activation of normal duration and amplitude, showed high root mean square values, and performed well in the range of control subjects. We conclude that the inability to suppress the activity of pathological oscillator(s) responsible for the action tremor plays a fundamental role in the bradykinesia associated with Parkinson's disease.
记录了12名帕金森病患者和6名正常对照者在水平面内进行大幅度（90度）上臂伸展的运动学特征以及肩部肌肉的同步活动。该运动由听觉“开始”信号触发，在运动前有一个等长内收动作。在所有个体（n = 18）中，观察到在运动加速阶段评估的主动肌肌电图活动的均方根值与峰值速度和加速度之间存在强正相关。在6名患者中，在前三角肌、中三角肌和后三角肌的运动阶段观察到频率为8 - 14Hz的震颤爆发（动作性震颤）：所有这些患者均方根值较低，相对于对照者存在运动迟缓。其余6名患者在运动阶段未出现这种动作性震颤。除1名患者外，所有患者主动肌激活的持续时间和幅度正常，均方根值较高，在对照者范围内表现良好。我们得出结论，无法抑制负责动作性震颤的病理性振荡器的活动在帕金森病相关的运动迟缓中起重要作用。
