Centre for Innovation and Technology Assessment in Health, Postgraduate Program in Electrical and Biomedical Engineering, Faculty of Electrical Engineering, Federal University of Uberlândia, Uberlândia, Brazil.
Institute of Physics, Federal University of Uberlândia, Uberlândia, Brazil.
Ann Biomed Eng. 2017 Nov;45(11):2614-2625. doi: 10.1007/s10439-017-1908-3. Epub 2017 Aug 29.
Parkinson's disease (PD) presents several motor signs, including tremor and bradykinesia. However, these signs can also be found in other motor disorders and in neurologically healthy older adults. The incidence of bradykinesia in PD is relatively high in all stages of the disorder, even when compared to tremor. Thus, this research proposes an objective assessment of bradykinesia in patients with PD (G : 15 older adults with Parkinson's disease, 65.3 ± 9.1 years) and older adults (G : 12 healthy older adults, 60.1 ± 6.1 years). The severity of bradykinesia in the participants of G was assessed using the Unified Parkinson's Disease Rating Scale. Movement and muscular activity were detected by means of inertial (accelerometer, gyroscope, magnetometer) and electromyographic sensors while the participants performed wrist extension against gravity with the forearm on pronation. Mean and standard error of inertial and electromyographic signal parameters could discriminate PD patients from healthy older adults (p value <0.05). In discriminating patients with PD from healthy older adults, the mean sensitivity and specificity were respectively 86.67 and 83.33%. The discrimination between the groups, based on the objective evaluation of bradykinesia, may contribute to the accurate diagnosis of PD and to the monitoring of therapies to control parkinsonian bradykinesia, and opens the possibility for further comparative studies considering individuals suffering from other motor disorders.
帕金森病（PD）表现出多种运动症状，包括震颤和运动迟缓。然而，这些症状也可能在其他运动障碍和神经健康的老年人中出现。在疾病的所有阶段，PD 患者的运动迟缓发生率都相对较高，甚至与震颤相比也是如此。因此，这项研究提出了一种客观评估 PD 患者（G：15 名帕金森病患者，65.3±9.1 岁）和老年人（G：12 名健康老年人，60.1±6.1 岁）运动迟缓的方法。使用统一帕金森病评定量表评估 G 组患者的运动迟缓严重程度。通过惯性（加速度计、陀螺仪、磁力计）和肌电传感器检测运动和肌肉活动，参与者在前臂旋前的情况下，对抗重力进行腕关节伸展。惯性和肌电信号参数的平均值和标准误差可区分 PD 患者和健康老年人（p 值<0.05）。在区分 PD 患者和健康老年人方面，平均灵敏度和特异性分别为 86.67%和 83.33%。基于运动迟缓的客观评估，对两组进行区分有助于 PD 的准确诊断和治疗方案以控制帕金森运动迟缓的监测，并为考虑患有其他运动障碍的个体的进一步比较研究提供了可能性。
