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关于霍奇金病中DNA合成淋巴细胞的命运

On the fate of DNA synthesizing lymphoid blood cells in Hodgkin's disease.

作者信息

Schick P, Trepel F, Begemann H

出版信息

Scand J Haematol. 1975 Mar;14(1):17-23. doi: 10.1111/j.1600-0609.1975.tb00289.x.

DOI:10.1111/j.1600-0609.1975.tb00289.x
PMID:1121644
Abstract

Autotransfusions of the DNA synthesizing blood cells from 2-2.5 liters of blood, labelled in vitro with 3H-thymidine, were performed in 2 patients with Hodgkin's disease. The fate of the labelled lymphoid cells was followed up for 5 min to 60 h in the circulating blood and occasionally in the lymph node tissue. The data indicate that 1) circulating DNA synthesizing large lymphoid cells leave the blood in less than 2 h; 2) they produce by mitosis large and medium sized lymphocytes, which mainly appear in blood and lymph nodes and 3) their generation time, in agreement with other estimates, is about 25 h.

摘要

对2例霍奇金病患者进行了自体输血,所输血液为2 - 2.5升经体外3H - 胸腺嘧啶标记的DNA合成血细胞。对标记的淋巴细胞在循环血液中以及偶尔在淋巴结组织中的命运进行了5分钟至60小时的随访。数据表明:1)循环中的DNA合成大淋巴细胞在不到2小时内离开血液;2)它们通过有丝分裂产生大、中型淋巴细胞,这些细胞主要出现在血液和淋巴结中;3)其生成时间与其他估计一致,约为25小时。

相似文献

1
On the fate of DNA synthesizing lymphoid blood cells in Hodgkin's disease.关于霍奇金病中DNA合成淋巴细胞的命运
Scand J Haematol. 1975 Mar;14(1):17-23. doi: 10.1111/j.1600-0609.1975.tb00289.x.
2
Quantitative cytology and cytochemistry of Hodgkin's tissue labelled in vivo with tritiated thymidine.用氚标记胸腺嘧啶核苷体内标记霍奇金组织的定量细胞学和细胞化学
Br J Cancer. 1973 Oct;28(4):332-9. doi: 10.1038/bjc.1973.156.
3
Spontaneously DNA synthesizing blood and spleen lymphocytes in Hodgkin's disease.霍奇金病中自发进行DNA合成的血液及脾脏淋巴细胞。
Scand J Haematol. 1981 Feb;26(2):97-105. doi: 10.1111/j.1600-0609.1981.tb01631.x.
4
Significance of the changes in the circulating lymphoid cells in Hodgkin's disease.霍奇金病中循环淋巴细胞变化的意义。
Br Med J. 1969 May 24;2(5655):473-7. doi: 10.1136/bmj.2.5655.473.
5
Kinetics of lymphocytes in Hodgkin's disease.霍奇金病中淋巴细胞的动力学
Blut. 1973 Oct;27(4):223-35. doi: 10.1007/BF01637435.
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Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes.霍奇金病中淋巴细胞转化受损。循环T淋巴细胞耗竭的证据。
J Clin Invest. 1973 Aug;52(8):1908-17. doi: 10.1172/JCI107374.
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The ultrastructural identification of tissue basophils and mast cells in Hodgkin's disease.霍奇金病中组织嗜碱性粒细胞和肥大细胞的超微结构鉴定
Lab Invest. 1975 Apr;32(4):469-75.
8
Different labelling patterns in mouse lymphoid tissues with [3H]deoxycytidine and [3H]thymidine.[3H]脱氧胞苷和[3H]胸苷标记小鼠淋巴组织的不同标记模式。
Cell Tissue Kinet. 1980 Jul;13(4):435-43. doi: 10.1111/j.1365-2184.1980.tb00483.x.
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In vitro cell proliferation studies in Hodgkin's disease.霍奇金病的体外细胞增殖研究。
Neoplasma. 1978;25(1):83-90.
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Autoradiography of activated lymphocytes in the blood in Hodgkin's disease.霍奇金病患者血液中活化淋巴细胞的放射自显影。
Isr J Med Sci. 1973 Jul;9(7):923-5.

引用本文的文献

1
Lymphocyte counts and functions in arterial and venous splenic blood of patients with Hodgkin's disease. Evidence for elimination of spontaneously DNA synthesizing cells in the spleen.霍奇金病患者脾动静脉血中淋巴细胞计数及功能。脾脏中自发进行DNA合成细胞被清除的证据。
Clin Exp Immunol. 1983 Jun;52(3):485-92.