Kato S
Department of Pediatrics, Tohoku University School of Medicine.
Nihon Rinsho. 2001 Feb;59(2):337-41.
Colonization of Helicobacter pylori depends on virulence factors of the organism, host factors and environmental factors. The prevalence of H. pylori differs between developing and Western developed countries, suggesting that the socioeconomic status influences the acquisition of the infection. The prevalence of Japanese children has been almost equal to that of Western countries. Although a main mode of transmission remains unclear, childhood is critical for acquisition of the infection. H. pylori causes gastritis (especially nodular gastritis) and duodenal ulcers in children but rarely gastric ulcers. No pediatric cases with H. pylori-associated gastric cancer have been reported. However, precancerous lesions including mucosal atrophy can develop in the infected children. Further studies in children are needed on strategy for H. pylori infection including prophylaxis of gastric cancer.
幽门螺杆菌的定植取决于该生物体的毒力因子、宿主因素和环境因素。幽门螺杆菌在发展中国家和西方发达国家的流行情况有所不同，这表明社会经济状况会影响该感染的获得。日本儿童中的幽门螺杆菌感染率几乎与西方国家相当。尽管主要传播途径尚不清楚，但儿童期是获得该感染的关键时期。幽门螺杆菌可导致儿童胃炎（尤其是结节性胃炎）和十二指肠溃疡，但很少引发胃溃疡。目前尚无幽门螺杆菌相关胃癌的儿科病例报告。然而，受感染儿童可能会出现包括黏膜萎缩在内的癌前病变。有必要针对儿童幽门螺杆菌感染的防治策略，包括胃癌预防，开展进一步研究。
