Ganss C, Gottwald B, Traenckner I, Kupfer J, Eis D, Mönch J, Gieler U, Klimek J
Department of Operative and Preventive Dentistry, Dental Clinic, Justus-Liebig-University, Schlangenzahl 14, 35392 Giessen, Germany.
Clin Oral Investig. 2000 Dec;4(4):206-11. doi: 10.1007/s007840000089.
The aim was to determine the relationship between mercury content of resting and stimulated saliva, and blood and urine. Eighty subjects participated; 40 of them attributed their self-reported complaints to dental amalgam (patients), the others were matched with respect to age, sex and amalgam restorations (controls). Serum, 24-h urine, resting and chewing stimulated saliva were analyzed for mercury using the ASS-technique. Quality, number, surfaces and total area of amalgam fillings were recorded clinically and using study models. Median (range) mercury levels in serum were 0.67 (0.1-1.52) microgram/l for patients and 0.60 (0.1-1.3) for controls. In urine levels were found to be 0.77 (0.11-5.16) and 0.94 (0.17-3.01) microgram/g creatinine respectively. No significant differences were found between the groups. Resting saliva contained 2.97 (0.10-45.46) micrograms/l in patients and 3.69 (0.34-55.41) in controls (not significant). Chewing mobilized an additional amount of 16.78 (-6.97 to 149.78) micrograms/l in patients and 49.49 (-1.36 to 504.63) in controls (P < or = 0.01). Only a weak correlation was found between mobilized mercury in saliva and serum (r = 0.27; P < or = 0.05) or urine (r = 0.47; P < or = 0.001). For resting saliva the respective values were r = 0.45 (P < or = 0.001) and r = 0.60 (P < or = 0.001). Saliva testing is not an appropriate measure for estimating the mercury burden derived from dental amalgam.
目的是确定静息唾液和刺激唾液中的汞含量与血液及尿液中汞含量之间的关系。80名受试者参与了研究；其中40人将其自我报告的不适归因于牙科汞合金（患者组），其他人在年龄、性别和汞合金修复情况方面进行了匹配（对照组）。采用ASS技术分析血清、24小时尿液、静息唾液和咀嚼刺激唾液中的汞含量。临床上并使用研究模型记录汞合金填充物的质量、数量、表面和总面积。患者组血清汞水平中位数（范围）为0.67（0.1 - 1.52）微克/升，对照组为0.60（0.1 - 1.3）微克/升。尿液中汞水平分别为0.77（0.11 - 5.16）和0.94（0.17 - 3.01）微克/克肌酐。两组之间未发现显著差异。患者组静息唾液中汞含量为2.97（0.10 - 45.46）微克/升，对照组为3.69（0.34 - 55.41）微克/升（无显著差异）。患者组咀嚼后唾液汞含量额外增加16.78（-6.97至149.78）微克/升，对照组增加49.49（-1.36至504.63）微克/升（P≤0.01）。仅发现唾液中动员的汞与血清（r = 0.27；P≤0.05）或尿液（r = 0.47；P≤0.001）之间存在弱相关性。对于静息唾液，相应的值分别为r = 0.45（P≤0.001）和r = 0.60（P≤0.001）。唾液检测并非估算牙科汞合金所致汞负荷的合适方法。
