Sharma A, Joshi S A, Srivastave S K, Bharadwaj R, Kahre P M
Department of Microbiology, NDMVP Medical College, Nasik.
Indian J Pathol Microbiol. 2000 Jul;43(3):337-41.
Fifty cases of hepato-renal dysfunction of unknown etiology were studied over a two-year period. Urine samples were examined microscopically and cultured for Leptospira. Serum samples were examined for antibodies against Leptospira by the Macroscopic slide agglutination test (MSAT). Seventeen out of fifty patients (34%) showed evidence of Leptospiral infection by at least two diagnostic techniques used. 15/17 i.e. 88.2% were positive by dark ground microscopy, 7/17 were diagnosed by culture technique and 16/17 i.e. 94% were confirmed by serology. There was a good correlation between Microscopic agglutination test (MAT) and MSAT. Thus Leptospires seem to play a major role in the causation of hepato-renal dysfunction in and around Pune, Maharashtra.
在两年时间里对50例病因不明的肝肾功能障碍病例进行了研究。对尿液样本进行显微镜检查并培养钩端螺旋体。通过宏观玻片凝集试验（MSAT）检测血清样本中抗钩端螺旋体的抗体。50名患者中有17名（34%）通过至少两种所使用的诊断技术显示有钩端螺旋体感染的证据。15/17（即88.2%）通过暗视野显微镜检查呈阳性，7/17通过培养技术确诊，16/17（即94%）通过血清学得到证实。显微镜凝集试验（MAT）和MSAT之间有良好的相关性。因此，钩端螺旋体似乎在马哈拉施特拉邦浦那及其周边地区肝肾功能障碍的病因中起主要作用。
