Sands M P, Sato S, Mohri H, Guntheroth W G, Merendino K A
Ann Thorac Surg. 1975 Apr;19(4):386-96. doi: 10.1016/s0003-4975(10)64040-4.
The influence of halothane, ether, carbon dioxide, and perfusion rewarming on the electrocardiogram was studied in 37 dogs subjected to surface-induced deep hypothermia. Significant anesthetic-related differences in P-R, QRS, Q-T and R-R intervals during cooling were not apparent; however, reduced arterial pressure, ventricular fibrillation, and a greater tendency for bradycardia requiring supportive measures were noted at low temperatures with halothane anesthesia. The use of 95% O2/5% CO2 significantly reduced the QTc at low temperatures; Other phenomena, including the occurrence and significance of J waves, are discussed. The relationship of the electrocardiogram to clinical and pathological results was evaluated and indicates that (1) properly managed resuscitation (manual massage and defibrillation) is not a serious hazard, (2) ether in 100% oxygen is the agent of choice for surface-induced deep hypothermia with prolonged circulatory arrest, and (3) halothane may be used in a procedure combining surface cooling and perfusion rewarming if given in a mixture of oxygen and carbon dioxide.
在37只接受体表诱导深度低温的犬中，研究了氟烷、乙醚、二氧化碳和灌注复温对心电图的影响。降温期间，P-R、QRS、Q-T和R-R间期在麻醉方面无显著差异；然而，在低温下使用氟烷麻醉时，动脉压降低、室颤以及更易出现需要支持措施的心动过缓。使用95% O2/5% CO2可显著降低低温时的QTc；还讨论了其他现象，包括J波的出现及意义。评估了心电图与临床及病理结果的关系，结果表明：（1）妥善管理的复苏（人工按摩和除颤）并非严重风险；（2）100%氧气中的乙醚是体表诱导深度低温并伴有长时间循环停止时的首选麻醉剂；（3）如果在氧气和二氧化碳混合气体中给予氟烷，则可用于体表冷却和灌注复温相结合的手术。
