Sands M P, Dillard D H, Hessel E A, Miller D W
Ann Thorac Surg. 1980 Feb;29(2):123-9. doi: 10.1016/s0003-4975(10)61649-9.
The halothane-diethyl ether azeotrope was evaluated in dogs as the anesthetic agent for deep surface hypothermia with total circulatory arrest for open-heart operation. All 10 animals given azeotrope in 100% oxygen (O2) experienced atrial arrhythmias during cooling, and 1 had ventricular fibrillation prior to the completion of cooling at 18 degrees to 20 degrees C. After only 30 minutes' arrest, 8 of the 10 dogs had postoperative motor disturbances. Administering the azeotrope in 95% O2 and 5% carbon dioxide (CO2) yielded markedly improved results characterized by a rapid, smooth cooling course, easy resuscitation following circulatory arrest, and rapid rewarming, and 3 out of 10 dogs experienced mild motor disturbance after 60 minutes of circulatory arrest. This method, when compared with our standard method of ether in 100% O2, resulted in reduced blood lactates and a striking improvement in clinical status on the first postoperative morning. In limited clinical trials, infants undergoing repair of congenital cardiac defects have done well and responded as expected based on the laboratory experience. Since the results with the azeotrope in 95% O2 and 5% CO2 were at least as good as, and in several instances better than, those with the standard method employing either, the nonexplosive characteristic of the azeotrope warrants continued evaluation of this agent.
对氟烷 - 乙醚共沸物进行了评估，将其作为用于心脏直视手术中深体表低温并完全循环停止的麻醉剂。在100%氧气（O₂）中给予共沸物的所有10只狗在降温过程中均出现房性心律失常，1只在体温降至18摄氏度至20摄氏度完成降温前发生室颤。仅30分钟的循环停止后，10只狗中有8只出现术后运动障碍。在95% O₂和5%二氧化碳（CO₂）中给予共沸物产生了明显改善的结果，其特点是降温过程快速、平稳，循环停止后易于复苏，复温迅速，10只狗中有3只在循环停止60分钟后出现轻度运动障碍。与我们在100% O₂中使用乙醚的标准方法相比，这种方法导致血乳酸降低，术后第一个早晨临床状况有显著改善。在有限的临床试验中，接受先天性心脏缺陷修复的婴儿情况良好，根据实验室经验反应符合预期。由于在95% O₂和5% CO₂中使用共沸物的结果至少与使用标准方法的结果一样好，而且在某些情况下更好，共沸物的非爆炸性特性值得继续对该药物进行评估。
