Sato S, Vanini V, Sands M P, Wong K C, Mohri H, Merendino K A
Ann Thorac Surg. 1975 Sep;20(3):299-307. doi: 10.1016/s0003-4975(10)64222-1.
The effects of Forane anesthesia for deep surface hypothermia with 30 minutes of total circulatory occlusion were evaluated. With 100% O2 6 of 7 dogs developed motor disorders postoperatively, while 3 of 5 with 98% O2/2% CO2 and none with 95% O2/5% CO2 developed motor disorders. Cooling was uneventful except for 1 episode of ventricular fibrillation in the 5% CO2 group at 23 degrees C. Resuscitation was easy, but the early rewarming period was characterized by repeated episodes of ventricular fibrillation and delayed recovery of cardiac function, especially in the 100% O2 group. Blood lactate levels remained low during cooling and gradually increased during rewarming in all groups, with the highest levels in the 100% O2 group and the lowest in the 5% CO2 group. It is concluded that Forane can be used for surface hypothermia with 30 minutes' circulatory occlusion when administered in 95% O2/5% CO2. A Comparison of these results with previously reported series indicates that Forane is inferior to ether but may be superior to halothane for surface hypothermia.
评估了氟烷麻醉用于深度体表低温并伴有30分钟完全循环阻断的效果。使用100%氧气时，7只狗中有6只术后出现运动障碍，而使用98%氧气/2%二氧化碳时，5只中有3只出现运动障碍，使用95%氧气/5%二氧化碳时无一只出现运动障碍。除了在5%二氧化碳组中23摄氏度时发生1次心室颤动外，降温过程顺利。复苏容易，但早期复温阶段的特点是反复出现心室颤动且心功能恢复延迟，尤其是在100%氧气组。所有组在降温期间血乳酸水平保持较低，复温期间逐渐升高，100%氧气组最高，5%二氧化碳组最低。结论是，当以95%氧气/5%二氧化碳给药时，氟烷可用于伴有30分钟循环阻断的体表低温。将这些结果与先前报道的系列进行比较表明，对于体表低温，氟烷比乙醚差，但可能比氟烷好。
