澳毒蛛蝎毒液的体内神经毒性：表明胸上神经系统与临床表现无关的证据。

In vivo neurotoxicity of Androctonus australis hector scorpion venom: evidence that the supra-thoracic nervous system is not implicated in the clinical manifestations.

作者信息

Clot-Faybesse O, Devaux C, Rochat H, Guieu R

机构信息

Université de la Méditerranée, CNRS UMR 6560, Laboratoire de Biochimie et d'Ingénierie des Protéines, IFR Jean-Roche, Faculté de Médecine Secteur Nord, Bd P. Dramard, 13916 Cedex 20, Marseille, Franc.e

出版信息

Toxicon. 2001 Jul;39(7):1003-7. doi: 10.1016/s0041-0101(00)00239-7.

DOI:10.1016/s0041-0101(00)00239-7

PMID:11223089

Abstract

The severity of scorpion stings is related to the highly active neurotoxins in the venom. In this study, rats whose supra-spinal central nervous system was deprived of its peripheral connections were experimentally poisoned by the venom of Androctonus australis hector scorpion. Clinical signs of severity were not modified when the rats had previously undergone high medullar section. These results suggest that the supra-thoracic nervous system is not implicated in the neurotoxicity manifestations of scorpion envenomation.

摘要

蝎子蜇伤的严重程度与毒液中高活性神经毒素有关。在本研究中，将脊髓以上中枢神经系统失去外周连接的大鼠用澳链尾蝎毒液进行实验性中毒。当大鼠先前接受高位延髓切断术后，严重程度的临床体征并未改变。这些结果表明，胸段以上神经系统与蝎子蜇伤的神经毒性表现无关。