Sugisawa H, Itou T, Sakai T
Department of Preventive Veterinary Medicine and Animal Health, Nihon University School of Veterinary Medicine, Kanagawa, Japan.
Biol Neonate. 2001 Feb;79(2):140-4. doi: 10.1159/000047080.
Bovine colostrum contains a variety of essential nutrients, antibodies, cytokines, hormones, and growth factors that are important for nutrient supply, host defense, growth and for general neonatal adaptation. We have investigated the effect of bovine colostrum on the phagocytic activity for latex particles by normal peripheral blood polymorphonuclear leukocytes using flow cytometric analysis. The phagocytosis promoting effect was observed in colostrum. The promoting activity showed dose-dependent increase up to 25% at a concentration of colostrum. This activity was maximum in the colostrum obtained at parturition and gradually decreased with the time course of lactation as well as IgG level. Colostrum possessed the higher promoting activity than milk and normal serum. These results indicate that bovine colostrum strongly activates polymorphonuclear leukocyte phagocytosis, suggesting the concernment with development of nonspecific immune system in newborns.
牛初乳含有多种必需营养素、抗体、细胞因子、激素和生长因子，这些对营养供应、宿主防御、生长以及新生儿的一般适应都很重要。我们使用流式细胞术分析研究了牛初乳对正常外周血多形核白细胞吞噬乳胶颗粒活性的影响。在初乳中观察到了吞噬促进作用。在初乳浓度达到25%之前，促进活性呈剂量依赖性增加。这种活性在分娩时获得的初乳中最高，并随着泌乳时间进程以及IgG水平逐渐降低。初乳比牛奶和正常血清具有更高的促进活性。这些结果表明，牛初乳强烈激活多形核白细胞吞噬作用，提示其与新生儿非特异性免疫系统发育有关。
