Cheng J C, Tang S P, Guo X, Chan C W, Qin L
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Chinese University of Hong Kong.
Spine (Phila Pa 1976). 2001 Feb 1;26(3):E19-23. doi: 10.1097/00007632-200102010-00002.
Bone biopsies from iliac crest and spinous process of adolescent idiopathic scoliosis patients were obtained intraoperatively for histology and histomorphometric analysis.
To study the histologic features of cancellous bone and to correlate the histomorphometric variables with preoperative bone mineral density in patients with adolescent idiopathic scoliosis.
Low bone mineral density has been reported in adolescent idiopathic scoliosis. However, there is limited information about the histopathologic changes.
Undecalcified and decalcified bone specimens from iliac crest and spinous process of adolescent idiopathic scoliosis patients obtained intraoperatively were stained with Goldner and hematoxylin & eosin stain, respectively. Results were correlated with bone mineral density of the lumbar spine (L2-L4) and proximal femur measured before surgery.
Bone histology showed significant less osteocyte count in the trabecular bone characterized with smooth and continuous borders in patients with adolescent idiopathic scoliosis. Histomorphometry confirmed the lower static parameters. The results correlated well with the decreased bone mineral density.
Bone biopsy study suggested disturbance of bone turnover in patients with adolescent idiopathic scoliosis. The abnormal metabolism might contribute to the low bone mineral density and play an important role in the etiology and pathogenesis of adolescent idiopathic scoliosis.
术中获取青少年特发性脊柱侧凸患者髂嵴和棘突的骨活检组织，用于组织学和组织形态计量学分析。
研究青少年特发性脊柱侧凸患者松质骨的组织学特征，并将组织形态计量学变量与术前骨密度进行关联。
已有报道称青少年特发性脊柱侧凸患者骨密度较低。然而，关于组织病理学变化的信息有限。
术中获取的青少年特发性脊柱侧凸患者髂嵴和棘突的未脱钙和脱钙骨标本，分别用戈德纳染色和苏木精-伊红染色。结果与术前测量的腰椎（L2-L4）和股骨近端的骨密度相关。
骨组织学显示青少年特发性脊柱侧凸患者小梁骨中骨细胞数量显著减少，小梁骨边界光滑连续。组织形态计量学证实了静态参数较低。结果与骨密度降低密切相关。
骨活检研究提示青少年特发性脊柱侧凸患者存在骨转换紊乱。异常代谢可能导致骨密度降低，并在青少年特发性脊柱侧凸的病因和发病机制中起重要作用。
