Vranken J H, Vissers K C, de Jongh R, Heylen R
Department of Anesthesiology, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Anesth Analg. 2001 Mar;92(3):625-8. doi: 10.1097/00000539-200103000-00013.
We evaluated the efficacy of intraarticular sufentanil in the prevention of postoperative pain after day-case arthroscopic procedures. Sixty patients were randomly assigned to receive either intraarticular sufentanil, 5 or 10 microg, and saline IV, or intraarticular saline and sufentanil 5 microg IV (control). All study medication was administered in a double-blinded fashion. Postoperatively and the day after surgery, pain levels at rest and during movement (i.e., active flexion of the knee), measured by a visual analog scale, were significantly lower in the Sufentanil groups compared with the Control group. Moreover, intraarticular sufentanil significantly reduced the postoperative consumption of analgesics. The time until discharge from the postanesthesia care unit (assessed by the Aldrete score) was significantly shorter in the patients receiving sufentanil intraarticularly. There were no significant differences between the two Sufentanil groups either in the intensity of postoperative pain or in discharge times from the postanesthesia care unit. We conclude that intraarticular sufentanil in arthroscopic knee procedures is a simple, effective, safe and well-tolerated analgesic technique for outpatients undergoing arthroscopic procedures. Increasing the dose sufentanil from 5 to 10 microg intraarticularly offered no additional advantage. Intraarticular sufentanil (5-10 microg) administration improves postoperative management after day-case diagnostic arthroscopic knee procedures.
Intraarticular sufentanil (5-10 microg) administration improves postoperative management after day-case diagnostic arthroscopic knee procedures.
我们评估了关节腔内注射舒芬太尼在日间膝关节镜手术后预防疼痛的疗效。60例患者被随机分配接受关节腔内注射5微克或10微克舒芬太尼并静脉注射生理盐水，或关节腔内注射生理盐水并静脉注射5微克舒芬太尼（对照组）。所有研究药物均采用双盲方式给药。术后及术后第一天，与对照组相比，舒芬太尼组患者静息和活动时（即膝关节主动屈曲）的疼痛程度，通过视觉模拟评分法测量，明显更低。此外，关节腔内注射舒芬太尼显著减少了术后镇痛药的用量。关节腔内注射舒芬太尼的患者从麻醉后恢复室出院的时间（通过Aldrete评分评估）明显更短。两组舒芬太尼组在术后疼痛强度或从麻醉后恢复室出院时间方面均无显著差异。我们得出结论，在膝关节镜手术中，关节腔内注射舒芬太尼对于接受关节镜手术的门诊患者是一种简单、有效、安全且耐受性良好的镇痛技术。将关节腔内舒芬太尼剂量从5微克增加到10微克并无额外优势。关节腔内注射舒芬太尼（5 - 10微克）可改善日间诊断性膝关节镜手术后的术后管理。
关节腔内注射舒芬太尼（5 - 10微克）可改善日间诊断性膝关节镜手术后的术后管理。
