Barnes E W, Irvine W J, Hunter W M, Ismail A A
Clin Endocrinol (Oxf). 1975 Jan;4(1):65-73. doi: 10.1111/j.1365-2265.1975.tb03305.x.
Two female volunteers, of menstrual age, with severe idiopathic hirsutism were treated for eight cycles and fifteen cycles respectively with cyproterone acetate 50 mg twice daily on days 5-14 of the cycle. In all but one cycle, ethinyl oestradiol in a dose of 50 mug daily from day 5 to 21 was given in addition. Cyproterone acetate when given alone abolished the mid-cycle LH surge. Combined therapy with cyproterone acetate and ethinyl oestradiol produced a significant improvement in both patients' hirsutism and was accompanied by a marked reduction in the urinary excretion of LH, FSH and androgens and by a fall in plasma testosterone. However, the clinical benefit derived from this drug was due principally to its action as a peripheral antiandrogen.
两名处于生育年龄的女性志愿者患有严重特发性多毛症，分别接受了8个周期和15个周期的治疗，在月经周期的第5 - 14天，每天两次服用50毫克醋酸环丙孕酮。除了一个周期外，在所有周期中，从第5天到第21天还额外给予了每日50微克的炔雌醇。单独使用醋酸环丙孕酮可消除月经周期中期的促黄体生成素高峰。醋酸环丙孕酮与炔雌醇联合治疗使两名患者的多毛症均有显著改善，同时伴有促黄体生成素、促卵泡生成素和雄激素的尿排泄量显著减少以及血浆睾酮水平下降。然而，这种药物带来的临床益处主要归因于其作为外周抗雄激素的作用。
