Evans E F, Proctor J D, Fratkin M J, Velandia J, Wasserman A J
Clin Pharmacol Ther. 1975 Jan;17(1):44-7. doi: 10.1002/cpt197517144.
Resting human muscle blood flow (MBF) was determined simultaneously in the usual intramuscular injection sites to resolve whether variance in MBF could account for differences in drug absorption. Three pairs of muscles (gluteus maximus, vastus lateralis, and deltoid) were studied in each of 20 adult subjects. Use of dual, matched linear rate meters allowed two muscles to be studied simultaneously, with the order of injection random within an incomplete block design. MBF was calculated from the 133xenon washout rate using a single exponential that the computer found to best fit the data. Deltoid MBF (11.6 ml/100 gm/min plus or minus 0.5) was significantly (p smaller than 0.05) greater than gluteus MBF (9.6 plus or minus 0.5), with vastus or between right and left sides for each muscle. These data indicate that there are consistent differencies in resting MBF among specific muscle groups of sufficient magnitude (19%) to affect the rate of absorption and peak serum levels following intramuscular administration of drugs.
在常规肌肉注射部位同时测定静息状态下人体肌肉血流量（MBF），以确定MBF的差异是否能解释药物吸收的差异。在20名成年受试者中，对三对肌肉（臀大肌、股外侧肌和三角肌）进行了研究。使用双匹配线性速率计可同时研究两块肌肉，在不完全区组设计中注射顺序随机。MBF通过计算机发现最能拟合数据的单指数从133氙清除率计算得出。三角肌MBF（11.6毫升/100克/分钟±0.5）显著（p小于0.05）高于臀大肌MBF（9.6±0.5），股外侧肌MBF或每块肌肉左右两侧之间的情况也是如此。这些数据表明，特定肌肉群之间静息MBF存在一致差异，其幅度足以影响肌肉注射药物后的吸收速率和血清峰值水平（19%）。
