Mauer S M, Paxson C L, von Hartizsch B, Buselmeier T J, Kjellstrand C M
Clin Pharmacol Ther. 1975 Jan;17(1):88-92. doi: 10.1002/cpt197517188.
A 10-month-old infant was treated with intensive supportive care and hemodialysis for severe propoxyphene intoxication. Dialysis clearance studies demonstrated that propoxyphene was removed from the serum at approximately 50% of the rate of blood urea nitrogen removal. Possibly because of tissue binding of the drug, the absolute quantity of propoxyphene removed by dialysis was small. The child survived the acute episode of intoxication but died of pulmonary complications several days later. The role of dialysis in propoxyphene intoxication remains to be established.
一名10个月大的婴儿因严重的丙氧芬中毒接受了强化支持治疗和血液透析。透析清除率研究表明，丙氧芬从血清中的清除速度约为血尿素氮清除速度的50%。可能由于药物与组织的结合，透析清除的丙氧芬绝对量很少。该患儿在急性中毒发作中幸存下来，但几天后死于肺部并发症。透析在丙氧芬中毒中的作用仍有待确定。
