Goodman J, Bessman A N
Clin Pharmacol Ther. 1975 Feb;17(2):167-70. doi: 10.1002/cpt1975172167.
The effects of intramuscular 200-mg nortestosterone decanoate (ND) on red cell 2,3 diphosphoglycerate (DPG) concentration and packed cell volumes (PCV) were compared in 9 patients undergoing chronic hemodialysis for renal failure and in 18 control patients undergoing hemodialysis but not receiving ND. Subjects had received the drug 4.3 plus or minus 0.3 (SEM.) months at the time of DPG determinations. DPG was similar in treated patients and in the control subjects: 6.27 plus or minus 0.22 mM/L RBC and 6.16 plus or minus 0.23 mM/L RBC, respectively. The initial PCV was also similar: 21.72% plus or minus 1.36 and 20.13% plus or minus 0.91. Although the mean PCV during treatment was higher for 5 of 9 ND-treated patients (p smaller than 0.01), the final PCV prior to termination of therapy was greater than the initial pretreatment PCV in only 2 of these 5 patients (p greater than 0.05). We conclude that 200 mg ND weekly has no effect on the red cell DPG and a transient unsustained effect in raising the PCV in male chronic hemodialysis patients over a 5-month period of treatment.
对9例因肾衰竭接受慢性血液透析的患者和18例接受血液透析但未使用癸酸诺龙（ND）的对照患者，比较了肌肉注射200毫克癸酸诺龙对红细胞2,3-二磷酸甘油酸（DPG）浓度和红细胞压积（PCV）的影响。在测定DPG时，受试者已接受该药物4.3±0.3（标准误）个月。治疗组患者和对照组受试者的DPG相似，分别为6.27±0.22 mM/L红细胞和6.16±0.23 mM/L红细胞。初始红细胞压积也相似：分别为21.72%±1.36和20.13%±0.91。虽然9例接受ND治疗的患者中有5例治疗期间的平均红细胞压积较高（p<0.01），但在这5例患者中，仅2例在治疗终止前的最终红细胞压积大于初始治疗前红细胞压积（p>0.05）。我们得出结论，每周200毫克ND对男性慢性血液透析患者的红细胞DPG无影响，且在5个月的治疗期间对提高红细胞压积有短暂的、不能持续的作用。
