Stephansson O, Dickman P W, Johansson A, Cnattingius S
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Am J Obstet Gynecol. 2001 Feb;184(3):463-9. doi: 10.1067/mob.2001.109591.
This study investigated whether the risk of antepartum stillbirth increases with body mass index during early pregnancy and also investigated the association between weight gain during pregnancy and the risk of antepartum stillbirth.
This population-based case-control study included 649 women with antepartum stillbirths and 690 control subjects among Swedish nulliparous women.
Compared with lean mothers (body mass index < or = 19.9 kg/m2), the odds ratios for risk of antepartum deaths were as follows: normal weight (body mass index, 20.0-24.9 kg/m2) odds ratio, 1.2 (95% confidence interval, 0.8-1.7); overweight (body mass index 25.0-29.9 kg/m2), odds ratio, 1.9 (95% confidence interval, 1.2-2.9); and obese (body mass index > or = 30.0 kg/m2) odds ratio, 2.1 (95% confidence interval, 1.2-3.6). For term antepartum death corresponding risks were even higher, with odds ratios of 1.6 (95% confidence interval, 0.9-2.6) for normal weight, 2.7 (95% confidence interval, 1.5-5.0) for overweight, and 2.8 (95% confidence interval, 1.3-6.0) for obese women, respectively. Maternal weight gain during pregnancy was not associated with risk of antepartum stillbirth.
Maternal overweight condition increased the risk of antepartum stillbirth, especially term antepartum stillbirth, whereas weight gain during pregnancy was not associated with risk.
本研究调查了孕早期体重指数升高是否会增加产前死产风险，同时也研究了孕期体重增加与产前死产风险之间的关联。
这项基于人群的病例对照研究纳入了649例瑞典未生育女性产前死产病例及690例对照对象。
与体重偏轻的母亲（体重指数≤19.9kg/m²）相比，产前死亡风险的比值比情况如下：正常体重（体重指数20.0 - 24.9kg/m²），比值比为1.2（95%置信区间0.8 - 1.7）；超重（体重指数25.0 - 29.9kg/m²），比值比为1.9（95%置信区间1.2 - 2.9）；肥胖（体重指数≥30.0kg/m²），比值比为2.1（95%置信区间1.2 - 3.6）。对于足月产前死亡，相应风险更高，正常体重者比值比为1.6（95%置信区间0.9 - 2.6），超重者为2.7（95%置信区间1.5 - 5.0），肥胖女性为2.8（95%置信区间1.3 - 6.0）。孕期母亲体重增加与产前死产风险无关。
母亲超重状况增加了产前死产风险，尤其是足月产前死产风险，而孕期体重增加与风险无关。
