Daga M K, Mishra T K, Mohan A
Department of Medicine and Biochemistry, Maulana Azad Medical College and Associated, Lok Nayak Hospital, New Delhi-110002.
J Assoc Physicians India. 1997 Nov;45(11):843-6.
30 patients with CT proven infarct presenting within 24 hours of the acute event were included in the study with 20 age and sex matched controls. On day 1 and day 15 of stroke, levels of plasma lipid peroxide (oxidant) and plasma alpha-tocopherol and beta carotene (antioxidant) were estimated. The patients were randomly assigned to two groups, one group receiving 300 mg/day of vitamin E for 15 days. Neurological examination was conducted according to Mathew scale on day 1 and day 15 and rehabilitation assessment was done at day 15 and at 6 weeks according to Barthel Index. On day 1, the mean value of plasma lipid peroxidation in controls was 4.97 +/- 1.44 nmol/ml and in stroke patients 5.89 +/- 1.56 nmol/ml (p < 0.05). The plasma beta-carotene in controls was 2.35 +/- 1.09 mg/L while in stroke patients was 1.07 +/- 0.55 mg/L (p < 0.001) and plasma alpha-tocopherol in control 9.74 +/- 2.76 micrograms/ml as compared to 7.57 +/- 2.92 micrograms/ml in stroke patients (p < 0.02). Initially the plasma lipid peroxide levels are high and antioxidant levels are low in patients of ischemic stroke. Exogenous vitamin E supplementation does not have any significant effect on early neurological outcome but it does bring about significant changes in subsequent recovery and rehabilitation of patients of stroke.
30例经CT证实为急性事件发生后24小时内出现梗死的患者被纳入该研究，并与20名年龄和性别匹配的对照者进行比较。在中风后的第1天和第15天，测定血浆脂质过氧化物（氧化剂）以及血浆α-生育酚和β-胡萝卜素（抗氧化剂）的水平。患者被随机分为两组，一组接受每日300毫克维生素E，共15天。在第1天和第15天根据马修量表进行神经学检查，并在第15天和6周时根据巴氏指数进行康复评估。第1天，对照组血浆脂质过氧化的平均值为4.97±1.44纳摩尔/毫升，中风患者为5.89±1.56纳摩尔/毫升（p<0.05）。对照组血浆β-胡萝卜素为2.35±1.09毫克/升，而中风患者为1.07±0.55毫克/升（p<0.001），对照组血浆α-生育酚为9.74±2.76微克/毫升，中风患者为7.57±2.92微克/毫升（p<0.02）。最初，缺血性中风患者的血浆脂质过氧化物水平较高，抗氧化剂水平较低。外源性补充维生素E对早期神经学结果没有任何显著影响，但确实会给中风患者的后续恢复和康复带来显著变化。
