GdmH在葡萄球菌羊毛硫抗生素加里德明和表皮菌素的产生菌免疫及分泌过程中的双重作用。
Dual role of GdmH in producer immunity and secretion of the Staphylococcal lantibiotics gallidermin and epidermin.
作者信息
Hille M, Kies S, Götz F, Peschel A
机构信息
Microbial Genetics, University of Tübingen, 72076 Tübingen, Germany.
出版信息
Appl Environ Microbiol. 2001 Mar;67(3):1380-3. doi: 10.1128/AEM.67.3.1380-1383.2001.
Abstract
The biosynthetic gene clusters of the staphylococcal lantibiotics epidermin and gallidermin are distinguished by the presence of the unique genes epiH and gdmH, respectively. They encode accessory factors for the ATP-binding cassette transporters that mediate secretion of the antimicrobial peptides. Here, we show that gdmH also contributes to immunity to gallidermin but not to nisin. gdmH alone affected susceptibility to gallidermin only moderately, but it led to a multiplication of the immunity level mediated by the FEG immunity genes when cloned together with the gdmT gene, suggesting a synergistic activity of the H and FEG systems. gdmH-related genes were identified in the genomes of several bacteria, indicating an involvement in further cellular functions.
摘要
葡萄球菌羊毛硫抗生素表皮菌素和加里德菌素的生物合成基因簇分别以独特基因epiH和gdmH的存在为特征。它们编码参与介导抗菌肽分泌的ATP结合盒转运蛋白的辅助因子。在此，我们表明gdmH也有助于对加里德菌素产生免疫，但对乳链菌肽没有作用。单独的gdmH仅适度影响对加里德菌素的敏感性，但当与gdmT基因一起克隆时，它会导致由FEG免疫基因介导的免疫水平倍增，表明H和FEG系统具有协同活性。在几种细菌的基因组中鉴定出了与gdmH相关的基因，表明其参与了更多的细胞功能。
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