三种大鼠品系在半胸照射后放射性肺损伤发展情况的比较。
Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation.
作者信息
van Eerde M R, Kampinga H H, Szabo B G, Vujaskovic Z
机构信息
Department of Radiotherapy, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
出版信息
Radiother Oncol. 2001 Mar;58(3):313-6. doi: 10.1016/s0167-8140(00)00301-7.
The purpose of this study is to define differences in radiation sensitivity among rat strains using breathing frequency and lung perfusion as end points of radiation-induced lung injury. The results have confirmed previous findings in mice showing that under stringently controlled iso-dose/volume irradiation conditions, substantial differences can be found in susceptibility to functional lung damage after radiation.
本研究的目的是利用呼吸频率和肺灌注作为辐射诱导肺损伤的终点，来确定大鼠品系之间辐射敏感性的差异。结果证实了先前在小鼠中的发现，即在严格控制的等剂量/体积照射条件下，辐射后对功能性肺损伤的易感性存在显著差异。
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