免疫抑制药物在小鼠实验中的相互作用，特别关注细菌移位。
Interaction of immunosuppressive drugs in mouse experiments with special regards to bacterial translocation.
作者信息
Anderlik P, Antmann K, Bános Z
机构信息
Institute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.
出版信息
Acta Microbiol Immunol Hung. 2001;48(1):107-13. doi: 10.1556/amicr.48.2001.1.10.
Following intraperitoneally (i.p.) applied treatment with 12.5 mg/mouse prednisolonum (PRD) no bacterial translocation (BT) was observed in mice. The PRD treatment applied in combination with lymphotropic cytostatics as dianhydrogalactitol (30 mg/kg i.p.) or chlorpromazine (75 mg/kg i.p.) both causing BT, did not increase the mice's drug sensitivity to the used agents. According to our results, PRD can be suitable for combined application with other immunosuppressive agents as it can increase immunosuppression without increase of side-effects such as those induced by bacterial translocation.
给小鼠腹腔内注射12.5mg/小鼠的泼尼松龙（PRD）进行治疗后，未观察到小鼠发生细菌移位（BT）。将PRD与亲淋巴细胞性细胞抑制剂联合使用，如双脱水半乳糖醇（腹腔注射30mg/kg）或氯丙嗪（腹腔注射75mg/kg），这两种药物都会导致BT，但并未增加小鼠对所用药物的药物敏感性。根据我们的结果，PRD可适用于与其他免疫抑制剂联合应用，因为它可以增强免疫抑制作用，而不会增加诸如细菌移位所诱导的副作用。
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